Asus G-Series if you can shell out the coin, hands down. My wife's G60 is an absolute beast! It has yet to even flinch at anything I've thrown at it.
However, there are some downsides. It burns through battery at an alarming rate, and weighs as much as a small house.
But, it plays games cranked right up, and makes short work of rendering. CAD works like butter on it.
She's a photographer, so she wanted the horsepower for some high end software.